个人简历
蓝茜,女,博士,西安交通大学医学部基础医学院生物化学与分子生物学系,讲师。主要从事长链非编码RNA的鉴定、代谢性疾病的分子机制研究。
教育经历
Ÿ 2009/9–2015/12, 西安交通大学, 生物化学与分子生物学, 博士,导师:吕社民。
Ÿ 2005/9–2009/7, 安徽医科大学, 生物技术, 学士。
科研与学术工作经历
Ÿ 2016/1-至今,西安交通大学,基础医学院生物化学与分子生物学系,讲师。
联系方式
西安交通大学医学部基础医学院生物化学与分子生物学系
Tel./Fax:+86-029-82657013
E-mail: lanxi.2016@xjtu.edu.cn
主持或参加科研项目(课题)及人才计划项目情况
1. 国家自然科学基金青年项目,81500840,新型机械敏感离子通道Piezo参与牙本质过敏反应及损伤修复的机制研究,2016/01-2018/12,18万元, 在研,参加。
2. 国家自然科学基金青年项目,81400232,Na+-K+-ATPase特异性DR抗体对大鼠心肌缺血/再灌注损伤的保护及分子机制研究,2015/01-2017/12,23万元,在研,参加。
3. 国家自然科学基金面上项目,81370952,TLR2介导的高脂高胆固醇诱导型NASH的发病机理,2014/01-2017/12,70万元,在研,参加。
4. 国家自然科学基金面上项目,81370123,血管心外膜活性物质(BVES)在哮喘导致的气道上皮损伤中的作用研究,2014/01-2014/12,16万元,已结题,参加。
5. 国家自然科学基金青年项目,31000608,硒敏感硒蛋白在氧自由基调控软骨细胞分化过程中的作用与机制,2011/01-2013/12,19万元,已结题,参加。
发表文章
1. Lan Xi #, Yan Jidong, Ren Juan, Zhong Bo, Li Jing, Li Yue, Liu Li, Yi Jing, Sun Qingzhu, Yang Xudong, Sun Jian, Meng Liesu, Zhu Wenhua, Holmdahl Rikard, Li Dongmin*, Lu Shemin*, A novel long noncoding RNA lnc-HC Binds hnRNPA2B1 to regulate expressions of Cyp7a1 and Abca1 in hepatocytic cholesterol metabolism. Hepatology, 2015, DOI(10.1002/hep.28391). (SCI, IF=11.055)
2. Lan Xi #, Li Dongmin #, Zhong Bo, Ren Juan, Wang Xuan, Sun Qingzhu, Li Yue, Liu Lee, Liu Li, Lu Shemin*, Identification of differentially expressed genes related to metabolic syndrome induced with high-fat diet in E3 rats. Exp Biol Med (Maywood), 2015, 240(2): 235-241. (SCI, IF=2.222)
3. Yang Wanyong #, Lan Xi, Li Dongmin, Li Tao*, Lu Shemin*, MiR-223 targeting MAFB suppresses proliferation and migration of nasopharyngeal carcinoma cells. BMC Cancer, 2015, 15:461-461.
4. Ma Jie, Lan Xi, Gao Ning, Wang Jin, Hao Dingjun, Yao Jianfeng, Huang Linhong, Zhang Rui*, Valenzuela Robert K. A genetic association study between common variants in the ABCA13 gene and schizophrenia in a Han Chinese population. Psychiatry Res, 2013, 209(3): 748-749.
5. Li Dongmin #, Wang Xuan #, Lan Xi, Li Yue, Liu Li, Yi Jing, Li Jing, Sun Qingzhu, Wang Yili, Li Hongmin, Zhong Nannan, Holmdahl Rikard, Lu Shemin*. Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats. Molecular and Cellular Endocrinology, 2015, 402: 1-12.
6. Wang Xuan #, Wang Meichen #, Li Hongmin, Lan Xi, Liu Li, Li Jiaxi, Li Yue, Li Jing, Yi Jing, Du Xiaojuan, Yan Jidong, Han Yan, Zhang Fujun, Liu Min, Lu Shemin, Li Dongmin*. Upregulation of miR-497 induced hepatic insulin resistance in E3 rats with HFD-MetS by targeting insulin receptor. Molecular and Cellular Endocrinology, 2015, 416:57-69.
7. Ren Juan, Li Dongmin, Li Yue, Lan Xi, Zheng Jianhuai, Wang Xuan, Ma Jie, Lu Shemin, HDAC3 interacts with sumoylatd C/EBPalpha to negatively regulate the LXRalpha expression in rat hepatocytes. Molecular and Cellular Endocrinology, 2013, 374(1-2): 35-45.
8. Zhong Bo, Yang Xudong, Sun Qingzhu, Liu Li, Lan Xi, Tian Jia, He Qirui, Hou Wei, Liu Haiyan, Jiang Congshan, Gao Ning, Lu Shemin*, Pdcd4 modulates markers of macrophage alternative activation and airway remodeling in antigen-induced pulmonary inflammation. Journal of Leukocyte Biology, 2014, 96(6): 1065-1075.
9. Li Dongmin #, Wang Xuan #, Ren Wuchao, Ren Juan, Lan Xi, Wang Feimiao, Li Hongmin, Zhang Fujun, Han Yan, Song Tianbao, Holdahl Rikard, Lu Shemin*, High expression of liver histone deacetylase 3 contributes to high-fat-induced metabolic syndrome by suppressing the PPAR-gamma and LXR-alpha-pathway in E3 rats. Molecular and Cellular Endocrinology, 2011, 344(1-2): 69-80.
10. Liu Li #, Sun Qingzhu #, Bao Rujuan, Roth Michael, Zhong Bo, Lan Xi, Tian Jia, He Qirui, Li Dongmin, Sun Jian, Yang Xudong*, Lu Shemin*, Specific regulation of PRMT1 expression by PIAS1 and PKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation. Scientific Reports, 2016, 6: 21810-21810.
11. Sun Qingzhu #, Liu Li #, Roth Michael, Tian Jia, He Qirui, Zhong Bo, Bao Rujuan, Lan Xi, Jiang Congshan, Sun Jian, Yang Xudong*, Lu Shemin*, PRMT1 upregulated by epithelial proinflammatory cytokines participates in COX2 expression in fibroblasts and chronic antigen-induced pulmonary inflammaton. The Journal of Immunology, 2015, 195(1): 298-306.
12. Sun Qingzhu #, Yang Xudong #, Zhong Bo, Jiao Fangfang, Li Chenyan, Li Dongmin, Lan Xi, Sun Jian, Lu Shemin, Upregualted protein arginine methyltransferase 1 by IL-4 increases eotaxin-1 expression in airway epithelial cells and participates in antigen-induced pulmonary inflammation in rats. The Journal of Immunology, 2012, 188(7): 3506-3512.
13. 蓝茜#,吕社民,李冬民*,Slc25a15基因与机体代谢的研究进展,国外医学.医学地理分册,2012,33(3):209-212。
14. 王璇,蓝茜,刘莉,伊静,李靖,李玥,王美晨,李嘉熙,宋刘梅,李冬民*, miR-144负性调节大鼠巨噬细胞TOLL样受体2的表达,南方医科大学学报,2015,(3):319-325。
15. 王美晨,王璇,蓝茜,李玥,伊静,李靖,宋刘梅,马莎蕊, 宁启兰,李冬民*,含miR-497野生及突变结合位点的胰岛素受体mRNA 3’UTR区报告基因载体的构建和鉴定,国外医学.医学地理分册,2014,(3):189-193。
16. 杨维娜,王璇,蓝茜,李玥,任娟,何岚,吕社民,李冬民*,2型糖尿病并发周围血管病变的临床流行病学分析,西安交通大学学报(医学版),2013,34(1):73-76。
17. 李嘉熙,宋刘梅,王美晨,蓝茜,李玥,刘莉,王璇,韩燕,李冬民*,获得构建miRNA高表达载体的pre-miRNA及其侧翼DNA序列的生物信息学方法,中国医学教育技术,2013,(5):546-549。