
蒋丛姗,西安交通大学医学部基础医学院生物化学与分子生物学系讲师,生物学博士
教育经历:2008年获西安交通大学生物工程学士学位,2014年获西安交通大学生物化学与分子生物学博士学位。
教学经历:从事医学部本科生《生物化学》及《分子生物学》中英文课程的教学工作。
科研经历:主要研究方向为microRNA家族及其调控体系在类风湿性关节炎中的作用机制。主持国家自然科学基金青年项目1项,中国博士后基金面上项目1项,西安交通大学校级基金1项,另参与国家级科研项目数十项。参与发表SCI实验论文19篇,其中第一作者5篇。
学术论文列表:
1. Jiang Congshan, Meng Liesu, Zhu Wenhua, Muhammad Shahzad, Yang Xudong and Lu Shemin. (2009) Housekeeping gene stability in pristane-induced arthritis and antigen-induced pulmonary inflammation of rats. Inflammation Research 58: 601-609.
2. Meng Liesu, Zhu Wenhua, Jiang Congshan, He Xiaojing, Hou Weikun, Zheng Fang, Holmdahl Rikard and Lu Shemin (2010) Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. Arthritis research & therapy 12: R103.
3. Hou Weikun, Meng Liesu, Tian Lifang, Zhu Wenhua, Jiang Congshan and Lu Shemin. (2010) A systematic comparison between collagen-induced arthritis and pristane-induced arthritis in Dark Agouti rats. Clinical and experimental rheumatology 28: 532-538.
4. Zhu Wenhua, Meng Liesu, Jiang Congshan, He Xiaojing, Hou Weikun, Xu Peng, Du Heng, Holmdahl Rikard and Lu Shemin. (2011) Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts. Arthritis research & therapy 13: R103.
5. Meng Liesu, He Xiaojing, Zhu Wenhua, Yang Xudong, Jiang Congshan, Sun Qingzhu, Muhammad Shahzad, Zhang Simeng, Xue Qian, Xie Xinfang and Lu Shemin. (2011) TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs. PLoS One 6: e17252.
6. Hou Weikun, Meng Liesu, Zheng Fang, Wen Yurong, Zhu Wenhua, Jiang Congshan, He Xiaojing, Zhou Yan and Lu Shemin. (2011) Methotrexate ameliorates pristane-induced arthritis by decreasing IFN-gamma and IL-17A expressions. Journal of Zhejiang University SCIENCE B 12: 40-46.
7. Zhu Wenhua, Meng Liesu, Jiang Congshan, Hou Weikun, Xu Jing, Wang Bo and Lu Shemin. (2012) Induction of toll-like receptor 2 positive antigen-presenting cells in spleen of pristane-induced arthritis in rats. Molecular Biology Reports 39:3667-73.
8. Zhu Wenhua, Meng Liesu, Jiang Congshan, Xu Jing, Wang Bo and Lu Shemin. (2012) Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats. Scandinavian Journal of Immunology 76: 263-270.
9. Wang Xiaomeng, Xu Jing, Li Yiping, Li Huan, Jiang Congshan, Yang Guangde, Lu Shemin and Zhang Sanqi. (2013) Synthesis and anticancer activity evaluation of a series of [1,2,4]triazolo[1,5-a]pyridinylpyridines in vitro and in vivo. European journal of medicinal chemistry 67: 243-251.
10. Jiang Congshan, Zhu Wenhua, Xu Jing, Wang Bo, Hou Weikun, Zhang Rui, Zhong Nannan, Ning Qilan, Han Yan, Yu Hongchuan, Sun Jian, Meng Liesu and Lu Shemin. (2014) MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats. Arthritis Research & Therapy 16: R9.
11. Zhong Bo, Yang Xudong, Sun Qingzhu, Liu Li, Lan Xi, Hou Wei, Liu Haiyan, Jiang Congshan, Meng Liesu, Gao Ning, Lu Shemin (2014). Pdcd4 modulates airway remodelling via influencing eosinophil recruitment and macrophage alternative activation in antigen induced pulmonary inflammation in rats. Leukocyte Biology 96(6): 1065-1075.
12. Jiang Congshan, Wang Xiaomeng, Zhang Sanqi, Zhu Wenhua, Xu Jing, Meng Liesu, and Shemin Lu. (2015) Discovery of 4-Benzoylamino-N-(Prop-2-yn-1-yl)benzamides as Novel MicroRNA-21 Inhibitors. Bioorganic & Medicinal Chemistry 23:6510-6519.
13. Zhu Wenhua#, Jiang Congshan#, Xu Jing, Wang Bo, Gao Fengjie, Tian Jia, Han Yan, Meng Liesu and Lu Shemin. (2015) Pristane primed T cells enhance TLR3 expression of fibroblast like synoviocytes via a TNF-alpha initiated P38 MAPK and NF-kappa pathways. Clinical Immunology 156(2):141-53.
14. Xu Jing, Jiang Congshan, Zhu Wenhua, Wang Bo, Yan Jidong, Min Zixin, Geng Manman, Han Yan, Ning Qilan, Zhang Fujun, Sun Jian, Meng Liesu, and Lu Shemin. (2015) NOD2 pathway via RIPK2 and TBK1 is involved in the aberrant catabolism induced by T-2 toxin in chondrocytes. Osteoarthritis Cartilage 23: 1575-1585.
15. Yan Zhou, Weikun Hou, Ke Xu, Dan Han, Congshan Jiang, Kuanhou Mou, Yue Li, Liesu Meng, Shemin Lu. (2015) The elevated expression of Th17-related cytokines is associated with skin lesion severity in early systemic sclerosis. Human Immunology 76(1):22-9.
16. Min Zixin, Zhang Rui, Yao Jianfeng, Jiang Congshan, Guo Yuanxu, Wang Wei, Tian Juan, Zhong Nan, Sun Jian, Ma Jie, and Lu Shemin. (2015) MicroRNAs associated with osteoarthritis differently expressed in bone matrix gelatin (BMG) rat model. International Journal of Clinical and Experimental Medicine 8(1):1009-1017.
17. Sun Qinzhu, Liu Li, Roth Michael, Tian Juan, He Qirui, Zhong Bo, Bao Rujuan, Lan Xi, Jiang Congshan, Sun Jian, Yang Xu, and Lu Shemin. (2015) PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation. Journal of Immunology 195(1):298-306.
18. Jiang Congshan, Yu Hongchuan, Sun Qingzhu, Zhu Wenhua, Xu Jing, Gao Ning, Zhang Rui, Liu Li, Wu Xiaoying, Yang Xudong, Meng Liesu* and Lu Shemin*. (2016) Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing. BMC pulmonary medicine 16:50.
19. Jiang Congshan, Zhu Wenhua, Xu Jing, Gao Ning, Zhang Rui, Meng Liesu and Shemin Lu. A simplified and optimal RT-qPCR strategy for extracellular miRNA profiling (2016 accepted, International Journal of Clinical and Experimental Medicine)