吕社民，男，55岁，博士，教授/博士生导师（在生物化学与分子生物学和医学免疫学学科招生），享受国务院政府特殊津贴专家，西安交通大学医学部基础医学院院长。主要研究领域：复杂性疾病易感基因的定位与克隆、慢性炎症性疾病的分子发病机理、动物模型的构建和评价。1982年毕业于西安医学院，获医学学士学位，1988年在西安医科大学获生物化学与分子生物学专业医学硕士学位， 2002年2月在瑞典Lund大学获分子免疫学与遗传学博士学位。1982年12月至1995年9月在西安医科大学地方性骨病研究所，历任研究实习员、助理研究员、副研究员，研究所副所长兼生化研究室主任。1995年l0月至2004年9月，在瑞典Lund大学医学院医学炎症研究所以高级访问学者及博士后研究人员从事研究工作，2004年6月被西安交通大学聘任为生物化学与分子生物学教授，任职于西安交大医学院遗传学与分子生物学系; 2005年1月任系主任，2015年任新成立的基础医学院院长。承担医学各专业本科生“生物化学”和“分子生物学”、研究生“分子生物学”和“Gene and Genome”及留学生“Biochemistry”和“Molecular Biology”课程的教学工作。主持校级“分子生物学”精品课程，省级“分子生物学”精品课程（2010；2012），校级研究生《医学分子生物学》精品课程。2007年西安交通大学医学院优秀科研团队负责人，2009年西安交通大学医学院研究生分子生物学教学改革优秀教学团队负责人，2010年西安交通大学遗传学与分子生物学优秀教学团队负责人，2014年陕西省生物化学与分子生物学教学团队负责人。培养的研究生已获博士学位者24名，2名外籍留学生，其中3名获西安交通大学优秀博士论文，硕士学位者13名。兼任医学部学术、教学和学位委员会委员；中国生物化学与分子生物学学会暨医学生物化学与分子生物学学会分会理事，陕西省生物化学与分子生物学学会副理事长，陕西省基础医学生物化学与分子生物学专业委员会主委；任《生命的化学》、《中国生物化学与分子生物学学报》、《西安交通大学学报》等杂志的编委；“Journal of Immunology”、“European Journal of Immunology”、“Arthritis Research and Therapy”等20中SCI杂志的审稿人，英国Arthritis Foundation、荷兰 Reamafonds和国家基金委等项目的评审专家。近5年的研究业绩包括：①创建了支气管哮喘的动物模型—AIPI，检测了肺脏和脾脏的PRMTs 表达谱，确定了PRMT1是调控AIPI 发生发展的一种关键表观遗传修饰酶，IL-4可通过诱导PRMT1 表达升高及其下游趋化因子的表达和分泌参与AIPI的发病机制。②通过对降植烷诱导的关节炎（PIA）的TLR筛选，及进一步的TLR 配体刺激、RNAi 等动物实验及细胞实验确定巨噬细胞和滑膜成纤维细胞中高表达的TLR3对PIA 发生发展具有重要调控作用，其表达可受到 miRNA26a的负调控。③通过近交系E3大鼠构建了高脂饮食诱导的胰岛素抵抗（HFD-IR）模型，发现其肝脏中HDAC3表达显著上调，上调的HDAC3可与sumo 化的C/EBPα结合负性调控LXRα表达；发现了一条新lnc-RNA，命名为lnc-HC，参与胆固醇的代谢。④通过Solexa 方法获得大鼠骨软骨发育microRNA 表达谱，发现23种miRNA 显著高调，6 种miRNA 显著低调，及86 个新miRNA 的基因座位、序列和表达谱；进一步研究显示miR-337通过靶基因TGFBR2 作用于TGF-β 通路，从而参与调节软骨的生成及发育。承担国家自然科学基金重点项目1项、面上项目3项、教育部博士点基金1项，陕西省国际科技合作重点项目1项，其它省部级课题4项。在SCI杂志上发表学术论文98篇，其中以通讯作者/第一作者发表的SCI论文52篇。译著2部，主编规划教材1部，参编规划教材9部。

 

详细联系方式

通讯地址：西安市雁塔区雁塔西路76号81号信箱

邮编：710061

固定电话/传真：029-82657764

手机：13571856898

电子信箱：lushemin@mail.xjtu.edu.cn或shemin.lu@gmail.com

 

发表的部分学术论文

[1]       Congshan Jiang，Hongchuan Yu, Qingzhu Sun, Wenhua Zhu, Jing X, Ning Gao, Rui Zhang5, Li Liu, Xiaoying Wu, Xudong Yang, Liesu Meng* and Shemin Lu*. Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing.　BMC Pulmonary Medicine 　　　(2016) 16:50. DOI 10.1186/s12890-016-0216-2

[2]       Liu L, Sun Q, Bao R, Roth M, Zhong B, Lan X, Tian J, He Q, Li D, Sun J, Yang X, Lu S*. Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation. Sci Rep. 2016 Feb 25;6:21810. doi: 10.1038/srep21810.

[3]       Sun Q, Liu L, Mandal J, Molino A, Stolz D, Tamm M, Lu S*, Roth M *. PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts. Cell Signal. 2016 Apr;28(4):307-15. doi: 10.1016/j.cellsig.2016.01.004. Epub 2016 Jan 18.

[4]       Xi Lan, Jidong Yan, Juan Ren, Bo Zhong, Jing Li, Yue Li, Li Liu, Jing Yi, Qingzhu Sun, Xudong Yang, Jian Sun, Liesu Meng, Wenhua Zhu, Rikard Holmdahl, Dongmin Li*, Shemin Lu*. A Novel Long Non-coding RNA Lnc-HC Binds hnRNPA2B1 to Regulate Expressions of Cyp7a1 and Abca1 in Hepatocytic Cholesterol Metabolism. Hepatology. 2015 Dec 11. doi: 10.1002/hep.28391.

[5]       Qingzhu Sun,  Li Liu, Michael Roth, Jia Tian, Qirui He, Bo Zhong, Ruanjuan Bao, Xi Lan, Congshan Jiang,  Jian Sun, Xudong Yang, Shemin Lu* . PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation. J Immunol. 2015 Jul 1;195(1):298-306.

[6]       Zixin Min, Rui Zhang, Jianfeng Yao, Congshan Jiang, Yuanxu Guo, Fei Cong, Wei Wang, Jia Tian, Nannan Zhong, Jian Sun, Jie Ma, Shemin Lu* •MicroRNAs associated with osteoarthritis differently expressed in bone matrix gelatin (BMG) rat model. Int J Clin Exp Med. 2015 Jan 15;8(1):1009-17.

[7]       Zixin Min, Wenxiang Zhao, Nannan Zhong, Yuanxu Guo, Mengyao Sun, Quancheng Wang, Rui Zhang, Jidong Yan, Lifang Tian,  Fujun Zhang, Yan Han, Qilan Ning, Liesu Meng, Jian Sun*, Shemin Lu* •Abnormality of epiphyseal plate induced by selenium deficiency diet in two generation DA rats. APMIS. 2015 Aug;123(8):697-705. doi: 10.1111/apm.12404.

[8]       Wanyong Yang, Xi Lan, Dongmin Li, Tao Li, Shemin Lu*. MiR-223 targeting MAFB suppresses proliferation and migration of nasopharyngeal carcinoma cells. BMC Cancer. 2015 Jun 9;15:461. doi: 10.1186/s12885-015-1464-x.

[9]       Jiang Congshan, Wang Xiaomeng, Zhang Sanqi*, Zhu Wenhua, Xu Jing, Meng Liesu, and Lu Shemin* Discovery of 4-Benzoylamino-N-(Prop-2-yn-1-yl)benzamides as Novel MicroRNA-21 Inhibitors Bioorg Med Chem. 2015 Oct 1;23(19):6510-9.

[10]   Lan X, Li D, Zhong B, Ren J, Wang X, Sun Q, Li Y, Liu L, Liu L, Lu S*.Identification of differentially expressed genes related to metabolic syndrome induced with high-fat diet in E3 rats. Exp Biol Med (Maywood). 2015 Feb; 240(2):235-41.

[11]   Xu J, Jiang C, Zhu W, Wang B, Yan J, Min Z, Geng M, Han Y, Ning Q, Zhang F, Sun J, Meng L, and Lu S*: NOD2 pathway via RIPK2 and TBK1 is involved in the aberrant catabolism induced by T-2 toxin in chondrocytes. Osteoarthritis Cartilage. 2015 Sep;23(9):1575-85. doi: 10.1016/j.joca.2015.04.016. Epub 2015 Apr 24.

[12]   Zhu W, Jiang C, Xu J, Geng M, Wu X, Sun J, Ma J, Holmdahl R, Meng L, and Lu S*: Pristane primed rat T cells enhance TLR3 expression of fibroblast-like synoviocytes via TNF-alpha initiated p38 MAPK and NF-kappaB pathways. Clin Immunol, 2014, 156(2):141-153.

[13]   Li D, Wang X, Lan X, Li Y, Liu L, Yi J, Li J, Sun Q, Wang Y, Li H, Zhong N, Holmdahl R, Lu S*. Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats. Mol Cell Endocrinol. 2015 Feb 15;402:1-12. doi: 10.1016/j.mce.2014.12.007. Epub 2014 Dec 19.

[14]   Zhu W, Jiang C, Xu J, Geng M, Wu X, Sun J, Ma J, Holmdahl R, Meng L, Lu S*. Pristane primed rat T cells enhance TLR3 expression of fibroblast-like synoviocytes via a TNF-α initiated p38 MAPK and NF-κB pathways. Clin Immunol. 2014 Dec 19. pii: S1521-6616(14)00272-1. doi: 10.1016/j.clim.2014.11.008. [Epub ahead of print] （通信作者）

[15]   Zhou Y, Hou W, Xu K, Han D, Jiang C, Mou K, Li Y, Meng L, Lu S*. The elevated expression of Th17-related cytokines and receptors is associated with skin lesion severity in early systemic sclerosis. Hum Immunol. 2015 Jan;76(1):22-29. doi: 10.1016/j.humimm.2014.12.008. Epub 2014 Dec 11. （通信作者）

[16]   Zhong B, Yang X, Sun Q, Liu L, Lan X, Tian J, He Q, Hou W, Liu H, Jiang C, Gao N, Lu S*. Pdcd4 modulates markers of macrophage alternative activation and airway remodeling in antigen-induced pulmonary inflammation. J Leukoc Biol. 2014 Dec;96(6):1065-75. doi: 10.1189/jlb.3A0313-136RRR. Epub 2014 Aug 5. （通信作者）

[17]   Zhou J, Han Y, Lu S. Direct role of interrod spacing in mediating cell adhesion on Sr-HA nanorod-patterned coatings. Int J Nanomedicine. 2014 Mar 8;9:1243-60. doi: 10.2147/IJN.S58236. eCollection 2014.

[18]   Jiang C, Zhu W, Xu J, Wang B, Hou W, Zhang R, Zhong N, Ning Q, Han Y, Yu H, Sun J, Meng L, Lu S*. MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats. Arthritis Res Ther. 2014 Jan 14;16(1):R9. doi: 10.1186/ar4435. （通信作者）

[19]   Dian-Lei Wu, Guang-Hua Xu, She-Min Lu, Bo-Lin Ma, Nai-Zhou Miao, Xiao-Bin Liu, Yan-ping Cheng, Ji-Hong Feng, Zhi-Gang Liu, Feng-Ding, Na-Liu, Wei-qin Li, Ying-Ren Zhao. Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B. Human Immunology. 2013. 74(5): 514–521.

[20]   Jidong Yan, Yuewen Zheng, Zixin Min, Qilan Ning, Shemin Lu*. Selenium effect on selenoprotein transcriptome in chondrocytes. BioMetals. 2013. 26(2): 285-296. （通信作者）

[21]   Xiaogang Jiang, Xudong Yang, Yan Han, Shemin Lu*. Transcription factor AP1 binds the functional region of the promoter and regulates gene expression of human PPARdelta in LoVo cell. Tumor Biology. 2013. 34 (6): 3619-3625.

[22]   Ren J, Li D, Li Y, Lan X, Zheng J, Wang X, Ma J, Lu S*. HDAC3 interacts with sumoylated C/EBPα to negatively regulate the LXRα expression in rat hepatocytes. Mol Cell Endocrinol. 2013. 374: 35-45.

[23]   Wu DL, Xu GH, Lu SM, Ma BL, Miao NZ, Liu XB, Cheng YP, Feng JH, Liu ZG, Feng-Ding, Na-Liu, Li WQ, Zhao YR. Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B. Hum Immunol. 2013; pii: S0198-8859(13)00033-5. (IF= 2.837)

[24]   Xu K, Xu P, Yao JF, Zhang YG, Hou WK, Lu SM*. Reduced apoptosis correlates with enhanced autophagy in synovial tissues of rheumatoid arthritis. Inflamm Res. 2013; 62(2):229-37. (IF= 2.109)

[25]   Lei L, Yuan X, Wang S, Zhang F, Han Y, Ning Q, Luo G, Lu S*. Mitogen-activated protein kinase pathways are involved in the upregulation of calcitonin gene-related peptide of rat trigeminal ganglion after organ culture. J Mol Neurosci. 2012; 48(1):53-65. (IF= 2.504)

[26]   Sun Q, Yang X, Zhong B, Jiao F, Li C, Li D, Lan X, Sun J, Lu S*. Upregulated protein arginine methyltransferase 1 by IL-4 increases eotaxin-1 expression in airway epithelial cells and participates in antigen-induced pulmonary inflammation in rats. J Immunol. 2012 1; 188(7):3506-12. (IF= 5.788)

[27]   Tian J, Yan J, Wang W, Zhong N, Tian L, Sun J, Min Z, Ma J, Lu S*. T-2 toxin enhances catabolic activity of hypertrophic chondrocytes through ROS-NF-κB-HIF-2α pathway. Toxicol In Vitro. 2012; 26(7):1106-13. (IF= 2.775)

[28]   Tuncel J, Haag S, Carlsén S, Yau AC, Lu S, Burkhardt H, Holmdahl R. Class II major histocompatibility complex-associated response to type XI collagen regulates the development of chronic arthritis in rats. Arthritis Rheum. 2012; 64(8):2537-47. (IF= 7.866)

[29]   Wu DL, Xu GH, Lu SM, Ma BL, Miao NZ, Liu XB, Feng JH, Liu N, Zeng QL, Hou WK, Pei L, Zhao Y. Age versus clinical virological characteristics in chronic hepatitis B virus infection: a case series study in China. Eur J Gastroenterol Hepatol. 2012; 24(4):406-13. (IF= 1.757)

[30]   Yan J, Tian J, Zheng Y, Han Y, Lu S*. Selenium promotes proliferation of chondrogenic cell ATDC5 by increment of intracellular ATP content under serum deprivation. Cell Biochem Funct. 2012; 30(8):657-63. (IF= 1.771)

[31]   Zhang R, Lu S, Meng L, Min Z, Tian J, Valenzuela RK, Guo T, Tian L, Zhao W, Ma J. Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia. PLoS One. 2012; 7(1):e30237. (IF= 4.092)

[32]   Zhang R, Yan JD, Valenzuela RK, Lu SM, Du XY, Zhong B, Ren J, Zhao SH, Gao CG, Wang L, Guo TW, Ma J. Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706. Schizophr Res. 2012; 141(1):40-7. (IF= 4.748)

[33]   Zhu W, Meng L, Jiang C, Hou W, Xu J, Wang B, Lu S*. Induction of toll-like receptor 2 positive antigen-presenting cells in spleen of pristane-induced arthritis in rats. Mol Biol Rep. 2012; 39(4):3667-73. (IF= 2.929)

[34]   Zhu W, Meng L, Jiang C, Xu J, Wang B, Han Y, Lu S*. Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats. Scand J Immunol. 2012; 76(3):263-70. (IF= 2.23)

[35]   Zuo M, Zheng YW, Lu SM, Li Y, Zhang SQ. Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC-EGFR dual inhibitors. Bioorg Med Chem. 2012; 20(14):4405-12. (IF= 2.921)

[36]   Cai Y, Cao YX, Lu SM, Xu CB, Cardell LO. Infliximab alleviates inflammation and ex vivo airway hyperreactivity in asthmatic E3 rats. Int Immunol. 2011; 23(7):443-51. (IF= 3.415)

[37]   Hou WK, Meng LS, Zheng F, Wen YR, Zhu WH, Jiang CS, He XJ, Zhou Y, Lu SM*. Methotrexate ameliorates pristane-induced arthritis by decreasing IFN-γ and IL-17A expressions. J Zhejiang Univ Sci B. 2011; 12(1):40-6. (IF= 1.099)

[38]   Li D, Wang X, Ren W, Ren J, Lan X, Wang F, Li H, Zhang F, Han Y, Song T, Holmdahl R, Lu S*. High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 rats. Mol Cell Endocrinol. 2011; 344(1-2):69-80. (IF= 4.192)

[39]   Liu SZ, Tian LF, Xu P, Zhuang GH, Zheng F, Tian J, Ning QL, Zhu BF, Lu SM*, Yan H. Analysis of correlation between blood biochemical indicators and bone mineral density of post-menopausal women. Mol Biol Rep. 2011; 38(2):939-48. (IF= 2.929)

[40]   Meng L, He X, Zhu W, Yang X, Jiang C, Sun Q, M B, Zhang S, Xue Q, Xie X, Lu S*. TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs. PLoS One. 2011; 6(2):e17252. (IF= 4.092)

[41]   Sun J, Sun Q, Lu S*. From selenoprotein to endochondral ossification: a novel mechanism with microRNAs potential in bone related diseases? Med Hypotheses. 2011; 77(5):807-11. (IF=1.15)

[42]   Sun J, Zhong N, Li Q, Min Z, Zhao W, Sun Q, Tian L, Yu H, Shi Q, Zhang F, Lu S*. MicroRNAs of rat articular cartilage at different developmental stages identified by Solexa sequencing. Osteoarthritis Cartilage. 2011; 19(10):1237-45. (IF=3.904)

[43]   Sun Q, Yang X, Asim MB, Jiao F, He X, Zhong B, Li D, Lu S*. Different challenge terms determine disease patterns of antigen-induced pulmonary inflammation in E3 rats. APMIS. 2011; 119(4-5):229-38. (IF=1.991)

[44]   Tian L, Wang W, Hou W, Tian J, Zhong N, Sun J, Guo D, Yao J, Xu P, Su P, He L, Lu S*. Autoimmune and inflammatory responses in Kashin-Beck disease compared with rheumatoid arthritis and osteoarthritis. Hum Immunol. 2011; 72(10):812-6. (IF=2.837)

[45]   Wang W, Zhong B, Sun J, Cao J, Tian J, Zhong N, Zhao W, Tian L, Xu P, Guo D, Ju X, Ma W, Li M, Hou W, Lu S*. Down-regulated HS6ST2 in osteoarthritis and Kashin-Beck disease inhibits cell viability and influences expression of the genes relevant to aggrecan metabolism of human chondrocytes. Rheumatology (Oxford). 2011; 50(12):2176-86. (IF=4.058)

[46]   Xie M, Dong Y, He L, Ren H, Ji Y, Lv S. Expression of VLA-4 molecule in PBMC from patients with hemorrhagic fever with renal syndrome. Inflamm Res. 2011; 60(7):613-7. (IF=2.109)

[47]   Xie M, Dong Y, Zhou Y, Ren H, Ji Y, Lv S. Levels of HTNV-specific CD8(+) T lymphocytes in PBMC from the patients with hemorrhagic fever with renal syndrome. Intern Emerg Med. 2011. [Epub ahead of print] (IF=2.057)

[48]   Zhang R, Valenzuela RK, Lu S, Meng L, Guo T, Du X, Kang W, Ma J. Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis. Schizophr Res. 2011; 133(1-3):159-64. (IF=4.748)

[49]   Zhang R, Lu SM, Qiu C, Liu XG, Gao CG, Guo TW, Valenzuela RK, Deng HW, Ma J. Population-based and family-based association studies of ZNF804A locus and schizophrenia. Mol Psychiatry. 2011; 16(4):360-1. (IF=13.668)

[50]   Zhao S, Liu E, Wei K, Lu S, Chu Y, Li Y, Wang Y, Huang B, Chen Y, Yang P. Interferon plus Chinese herbs are associated with higher sustained virological response than interferon alone in chronic Hepatitis C: a meta-analysis of randomised trials. Antiviral Res. 2011; 89(2):156-64. (IF=4.301)

[51]   Zhong N, Zhang R, Qiu C, Yan H, Valenzuela RK, Zhang H, Kang W, Lu S, Guo T, Ma J. A novel replicated association between FXYD6 gene and schizophrenia. Biochem Biophys Res Commun. 2011; 405(1):118-21. (IF=2.484)

[52]   Zhu W, Meng L, Jiang C, He X, Hou W, Xu P, Du H, Holmdahl R, Lu S*. Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts. Arthritis Res Ther. 2011; 13(3):R103. (IF=4.445)

[53]   Guo Y, Yao F, Lu S, Cao DY, Reed WR, Zhao Y. The major histocompatibility complex genes are associated with basal pain sensitivity differences between Dark-Agouti and novel congenic DA.1U rats. Life Sci. 2010; 86(25-26):972-8. (IF=2.527)

[54]   Hou W, Meng L, Tian L, Zhu W, Jiang C, Lu S*. A systematic comparison between collagen-induced arthritis and pristane-induced arthritis in Dark Agouti rats. Clin Exp Rheumatol. 2010; 28(4):532-8. (IF=2.148)

[55]   Ma J, Li DM, Zhang R, Yang XD, Gao CG, Lu SM*, Wu SN, Wang L. Genetic analysis of glutamate cysteine ligase modifier (GCLM) gene and schizophrenia in Han Chinese. Schizophr Res. 2010; 119(1-3):273-4. (IF=4.748)

[56]   Meng L, Zhu W, Jiang C, He X, Hou W, Zheng F, Holmdahl R, Lu S*. Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. Arthritis Res Ther. 2010; 12(3):R103. (IF=4.445)

[57]   Raza Asim MB, Shahzad M, Yang X, Sun Q, Zhang F, Han Y, Lu S*. Suppressive effects of black seed oil on ovalbumin induced acute lung remodeling in E3 rats. Swiss Med Wkly. 2010; 140:w13128. (IF=1.895)

[58]   Yang W, Lv S*, Liu X, Liu H, Yang W, Hu F. Up-regulation of Tiam1 and Rac1 correlates with poor prognosis in hepatocellular carcinoma. Jpn J Clin Oncol. 2010; 40(11):1053-9. (IF=1.783)

[59]   Yang X, Sun Q, Asim MB, Jiang X, Zhong B, Shahzad M, Zhang F, Han Y, Lu S*. Nitric oxide in both bronchoalveolar lavage fluid and serum is associated with pathogenesis and severity of antigen-induced pulmonary inflammation in rats. J Asthma. 2010; 47(2):135-44. (IF=1.525)

[60]   Yu HB, Liu EQ, Lu SM, Zhao SH. Treatment with peginterferon versus interferon in Chinese patients with hepatitis B. Biomed Pharmacother. 2010; 64(8):559-64. (IF=2)

[61]   Zhao S, Liu E, Chen P, Cheng D, Lu S, Yu Q, Wang Y, Wei K, Yang P. A comparison of peginterferon α-2a and α-2b for treatment-naive patients with chronic hepatitis C virus: A meta-analysis of randomized trials. Clin Ther. 2010; 32(9):1565-77. (IF=2.321)

[62]   Jiang C, Meng L, Zhu W, Shahzad M, Yang X, Lu S*. Housekeeping gene stability in pristane-induced arthritis and antigen-induced pulmonary inflammation of rats. Inflamm Res. 2009; 58(9):601-9. (IF=2. 109)

[63]   Li D, Ren W, Wang X, Wang F, Gao Y, Ning Q, Han Y, Song T, Lu S*. A modified method using TRIzol reagent and liquid nitrogen produces high-quality RNA from rat pancreas. Appl Biochem Biotechnol. 2009; 158(2):253-61. (IF=1.943)

[64]   Liu SZ, Yan H, Hou WK, Xu P, Tian J, Tian LF, Zhu BF, Ma J, Lu SM*. Relationships between endothelial nitric oxide synthase gene polymorphisms and osteoporosis in postmenopausal women. J Zhejiang Univ Sci B. 2009; 10(8):609-18. (IF=1.099)

[65]   Liu SZ, Yan H, Xu P, Li JP, Zhuang GH, Zhu BF, Lu SM*. Correlation analysis between bone mineral density and serum element contents of postmenopausal women in Xi'an urban area. Biol Trace Elem Res. 2009; 131(3):205-14. (IF=1.923)

[66]   Long JW, Yang XD, Cao L, Lu SM, Cao YX. Alteration of airway responsiveness mediated by receptors in ovalbumin-induced asthmatic E3 rats. Acta Pharmacol Sin. 2009; 30(7):965-72. (IF=1.953)

[67]   Ma J, Sun J, Zhang H, Zhang R, Kang WH, Gao CG, Liu HS, Ma XH, Min ZX, Zhao WX, Ning QL, Wang SH, Zhang YC, Guo TW, Lu SM*. Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample. Neurosci Lett. 2009; 462(2):105-8. (IF=2.105)

[68]   Shahzad M, Yang X, Raza Asim MB, Sun Q, Han Y, Zhang F, Cao Y, Lu S*. Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats. Pulm Pharmacol Ther. 2009; 22(1):37-43. (IF=2.8)

[69]   Yao F, Guo Y, Lu S, Sun C, Zhang Q, Wang H, Zhao Y. Mechanical hyperalgesia is attenuated by local administration of octreotide in pristane-induced arthritis in Dark-Agouti rats. Life Sci. 2008; 83(21-22):732-8. (IF=2.527)

[70]   Carlsen S, Lu S, Holmdahl R. Arthritis induced with minor cartilage proteins. Methods Mol Med. 2007; 136:225-42.

[71]   Holmberg J, Tuncel J, Yamada H, Lu S, Olofsson P, Holmdahl R. Pristane, a non-antigenic adjuvant, induces MHC class II-restricted, arthritogenic T cells in the rat. J Immunol. 2006; 176(2):1172-9. (IF=5.788)

[72]   Dzhambazov B, Holmdahl M, Yamada H, Lu S, Vestberg M, Holm B, Johnell O, Kihlberg J, Holmdahl R. The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans. Eur J Immunol. 2005; 35(2):357-66. (IF=5.103)

[73]   Olofsson P, Johansson A, Wedekind D, Klöting I, Klinga-Levan K, Lu S, Holmdahl R. Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1. Genomics. 2004; 83(5):765-71. (IF=3.019)

[74]   Olofsson P, Lu S, Holmberg J, Song T, Wernhoff P, Pettersson U, Holmdahl R. A comparative genetic analysis between collagen-induced arthritis and pristane-induced arthritis. Arthritis Rheum. 2003; 48(8):2332-42. (IF=7.866)

[75]   Olofsson P, Holmberg J, Tordsson J, Lu S, Akerström B, Holmdahl R. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet. 2003; 33(1):25-32. (IF=35.532)

[76]   Lu S, Carlsen S, Hansson AS, Holmdahl R. Immunization of rats with homologous type XI collagen leads to chronic and relapsing arthritis with different genetics and joint pathology than arthritis induced with homologous type II collagen. J Autoimmun. 2002; 18(3):199-211. (IF=7.368)

[77]   Lu S, Nordquist N, Holmberg J, Olofsson P, Pettersson U, Holmdahl R. Both common and unique susceptibility genes in different rat strains with pristane-induced arthritis. Eur J Hum Genet. 2002; 10(8):475-83. (IF=4.4)

 

 

主持及参与的科研项目

l   国家自然科学基金重点项目：围孕期微营养素干预对先天性心脏病发生的一级预防作用及其机制；Project No.81230016。2013.1－2017.12；280万；第四位；承担工作：分子流行病学。

l   教育部博士点基金-博导类：降植烷诱导自噬参与免疫调节的分子机制研究；项目号：20110201110044；2012.1.1—2014.12.30；12万元。

l   国家自然科学基金面上项目：肺固有细胞中组蛋白修饰酶对哮喘气道重塑的作用机制研究；项目号：81170017；2012.1—2015.12；55万元。项目主持人：吕社民。

l   国家自然科学基金面上项目：蛋白质精氨酸甲基转移酶在哮喘中的作用机制研究；项目号：81070030；2011.1—2011.12； 10万元。项目主持人：吕社民。

l   国家自然科学基金面上项目：《PIA 模型大鼠Toll 样受体基因表达增高的分子机制研究》；项目号：30801027；2009.1—2011.12； 20万元。第二主持人，项目指导：吕社民。

l   国家自然科学基金重点项目：大骨节病病因及发病机制研究；Project No. 30630058；2007年－2010 年；145 万。项目主持人：吕社民。

l   教育部春晖计划：先天性免疫细胞和分子及其在炎症中作用的分子机理；主持人：吕社民；2005年－2007年；3万。

l   教育部春晖计划：Annexin I对NOCIA大鼠的影响及其影响机制的研究；主持人：吕社民；2006年－2008年；3万。

l   国家自然科学基金面上项目：用NOCIA大鼠模型筛选和鉴定类风湿关节炎的易感基因；Project No. 30571725。2006年－2008年；28万；项目主持人：吕社民。

l   2007年陕西省国际科技合作重点项目：以慢性免疫性疾病为对象，开展“疾病－基因－药物”的研究，2007.7-2009.6，Project No. 2007KW－06, 5万元

l   教育部“留学回国人员科研启动基金”： 用大鼠模型鉴定类风湿关节炎的易感基因，2005.1-2005.12。项目号[2005]546，经费4万。

 

 

主编及参编书籍

（1）    吕社民、刘学政主编. 内分泌系统.人民卫生出版社. 2015年12月.

（2）    吕社民、刘学政主编. 内分泌系统学习指导及习题集.人民卫生出版社. 2016年4月.

（3）    周春燕、冯作华主编. 医学分子生物学. 第2版..人民卫生出版社.2014年5月.

（4）    药立波主编. 医学分子生物学实验技术. 第3版.人卫生出版社.2014.5

（5）    吕社民, 李冬民, 孟列素等主译. 细胞生物学实验方案. 化学工业出版社. 2009.9. 书号：978-7-122-06167-6

（6）    吕社民主译. 世界最新英汉双解细胞与分子生物学词典. 世界图书出版社. 2008.1. 书号：ISBN 978-7-5062-7574-3

（7）    马文丽主编. 国家精品课程教材，中国科学院教材建设专家委员会规划教材，全国高等医药院校规划教材. 生物化学. 第1版. 2012.7. 书号：ISBN 978-7-03-034386-4.

（8）    药立波主编. 卫生部“十二五”规划教材，全国高等医药教材建设研究会“十二五”规划教材，全国高等学校医学研究生规划教材. 医学分子生物学实验技术 第2版. 人民卫生出版社. 2011.7. 书号：978-7-117-14421-6/R·14422

（9）    贾弘褆，冯作化主编. 全国高等学校教材 供8年制及7年制临床医学等专业用. 普通高等教育“十一五”国家级规划教材，卫生部“十一五”规划教材. 生物化学与分子生物学 第2版. 人民卫生出版社. 2010.8. 书号：ISBN 978-7-117-13051-6/R·13052

（10）童坦军，李刚主编. 全国高等医学院教材 生物化学第2版.北京大学医学出版社. 2009.8. 书号：ISBN 978-7-81116-791-7

（11）药立波主编. 全国高等学校教材 医学分子生物学第3版（普通高等教育“十一五”国家级规划教材; 卫生部“十一五”规划教材; 全国高等医药教材建设研究会规划教材）. 人民卫生出版社. 2008.6. 书号：ISBN 978-7-117-10168-4/R·10169

（12）贾弘褆主编. 全国高等学校教材英文版 生物化学（卫生部“十一五”规划教材; 全国高等医药教材建设研究会规划教材）. 人民卫生出版社. 2007.8. 书号：ISBN 978-7-117-09004-9/R·9005

 

学术兼职

（1）    2006，陕西省生物化学与分子生物学学会副理事长

（2）    2007，中国生物化学与分子生物学学会医学生物化学与分子生物学学会分会理事

（3）    陕西省基础医学生物化学与分子生物学专业委员会主委

（4）    西安交通大学医学院学术委员会委员

（5）    2006，西安交通大学学报医学版，编委

（6）    2010，国外医学地理学分册，编委

（7）    2010, 生命的化学，编委

（8）    2015，中国生物化学与分子生物学学报，编委

 

 

Publications (since 2008, * corresponding author)

 

[1]       Congshan Jiang，Hongchuan Yu, Qingzhu Sun, Wenhua Zhu, Jing X, Ning Gao, Rui Zhang5, Li Liu, Xiaoying Wu, Xudong Yang, Liesu Meng* and Shemin Lu*. Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing.　BMC Pulmonary Medicine (2016) 16:50. DOI 10.1186/s12890-016-0216-2

[2]       Liu L, Sun Q, Bao R, Roth M, Zhong B, Lan X, Tian J, He Q, Li D, Sun J, Yang X, Lu S*. Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation. Sci Rep. 2016 Feb 25;6:21810. doi: 10.1038/srep21810.

[3]       Sun Q, Liu L, Mandal J, Molino A, Stolz D, Tamm M, Lu S*, Roth M *. PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts. Cell Signal. 2016 Apr;28(4):307-15. doi: 10.1016/j.cellsig.2016.01.004. Epub 2016 Jan 18.

[4]       Xi Lan, Dongmin Li, Bo Zhong, Juan Ren, Xuan Wang,Qingzhu Sun, Yue Li, Lee Liu, Li Liu, Shemin Lu*. Identification of differentially expressed genes related to metabolic syndrome induced with high-fat diet in E3 rats. Experimental biology and medicine (Maywood, N.J.) 10/2014; DOI: 10.1177/1535370214554531

[5]       Bo Zhong, Xudong Yang, Qingzhu Sun, Li Liu, Xi Lan, Jia Tian,Qirui He, Wei Hou, Haiyan Liu, Congshan Jiang, Ning Gao,Shemin Lu*。 Pdcd4 modulates markers of macrophage alternative activation and airway remodeling in antigen-induced pulmonary inflammation. Journal of leukocyte biology 08/2014; DOI: 10.1189/jlb.3A0313-136RRR

[6]       Congshan Jiang, Wenhua Zhu, Jing Xu, Bo Wang, Weikun Hou,Rui Zhang, Nannan Zhong, Qilan Ning, Yan Han, Hongchuan Yu,Jian Sun, Liesu Meng, Shemin Lu*. MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats. Arthritis research & therapy 01/2014; 16(1):R9.  

[7]       Run Huang, Yong Han, Shemin Lu。 Enhanced osteoblast functions and bactericidal effect of Ca and Ag dual-ion implanted surface layers on nanograined titanium alloys. J. Mater. Chem. B 06/2014; 2(28). DOI: 10.1039/C4TB00124A

[8]       Jianhong Zhou, Yong Han, Shemin Lu. Direct role of interrod spacing in mediating cell adhesion on Sr-HA nanorod-patterned coatings. International Journal of Nanomedicine 01/2014; 9:1243-60.  

[9]       Bo-Rui Kang, Ai-Lin Shan, Yi-Ping Li, Jing Xu, She-Min Lu, San-Qi Zhang.Discovery of 2-aryl-8-hydroxy (or methoxy)-isoquinolin-1(2H)-ones as novel EGFR inhibitor by scaffold hopping. Bioorganic & medicinal chemistry 09/2013

[10]   Xiaogang Jiang, Xudong Yang, Yan Han, Shemin Lu*. Transcription factor AP1 binds the functional region of the promoter and regulates gene expression of human PPARdelta in LoVo cell. Tumor Biology 07/2013; 34(6):3619-25

[11]   Juan Ren, Dongmin Li, Yue Li, Xi Lan, Jianhuai Zheng, Xuan Wang, Jie Ma, Shemin Lu. HDAC3 interacts with sumoylated C/EBPα to negatively regulate the LXRα expression in rat hepatocytes. Molecular and Cellular Endocrinology. DOI:10.1016/j.mce.2013.04.013;374(1-2):35-45

[12]   Run Huang, Shemin Lu, Yong Han. Role of grain size in the regulation of osteoblast response to Ti-25Nb-3Mo-3Zr-2Sn alloy. Colloids and surfaces. B, 06/2013; 111C:232-241.

[13]   Yan J, Zheng Y, Min Z, Ning Q, Lu S*. Selenium effect on selenoprotein transcriptome in chondrocytes. Biology of Metals. 2013; DOI:10.1007/s10534-013-9610-x;26(2):285-96

[14]   Jianhong Zhou, Bo Li, Shemin Lu, Lan Zhang, Yong Han. Regulation of osteoblast proliferation and differentiation by interrod spacing of Sr-HA nanorods on microporous titania coatings. Materials & Interfaces. 05/2013; DOI:10.1021/am401339n

[15]   Wu DL, Xu GH, Lu SM*, Ma BL, Miao NZ, Liu XB, Cheng YP, Feng JH, Liu ZG, Feng-Ding, Na-Liu, Li WQ, Zhao YR. Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B. Hum Immunol. 2013; pii: S0198-8859(13)00033-5.

[16]   Xu K, Xu P, Yao JF, Zhang YG, Hou WK, Lu SM*. Reduced apoptosis correlates with enhanced autophagy in synovial tissues of rheumatoid arthritis. Inflamm Res. 2013; 62(2):229-37.

[17]   Lei L, Yuan X, Wang S, Zhang F, Han Y, Ning Q, Luo G, Lu S*. Mitogen-activated protein kinase pathways are involved in the upregulation of calcitonin gene-related peptide of rat trigeminal ganglion after organ culture. J Mol Neurosci. 2012; 48(1):53-65.

[18]   Sun Q, Yang X, Zhong B, Jiao F, Li C, Li D, Lan X, Sun J, Lu S*. Upregulated protein arginine methyltransferase 1 by IL-4 increases eotaxin-1 expression in airway epithelial cells and participates in antigen-induced pulmonary inflammation in rats. J Immunol. 2012 ; 188(7):3506-12.

[19]   Tian J, Yan J, Wang W, Zhong N, Tian L, Sun J, Min Z, Ma J, Lu S*. T-2 toxin enhances catabolic activity of hypertrophic chondrocytes through ROS-NF-κB-HIF-2α pathway. Toxicol In Vitro. 2012; 26(7):1106-13.

[20]   Tuncel J, Haag S, Carlsén S, Yau AC, Lu S, Burkhardt H, Holmdahl R. Class II major histocompatibility complex-associated response to type XI collagen regulates the development of chronic arthritis in rats. Arthritis Rheum. 2012; 64(8):2537-47.

[21]   Wu DL, Xu GH, Lu SM*, Ma BL, Miao NZ, Liu XB, Feng JH, Liu N, Zeng QL, Hou WK, Pei L, Zhao Y. Age versus clinical virological characteristics in chronic hepatitis B virus infection: a case series study in China. Eur J Gastroenterol Hepatol. 2012; 24(4):406-13.

[22]   Yan J, Tian J, Zheng Y, Han Y, Lu S*. Selenium promotes proliferation of chondrogenic cell ATDC5 by increment of intracellular ATP content under serum deprivation. Cell Biochem Funct. 2012; 30(8):657-63.

[23]   Zhang R, Lu S, Meng L, Min Z, Tian J, Valenzuela RK, Guo T, Tian L, Zhao W, Ma J. Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia. PLoS One. 2012; 7(1):e30237.

[24]   Zhang R, Yan JD, Valenzuela RK, Lu SM, Du XY, Zhong B, Ren J, Zhao SH, Gao CG, Wang L, Guo TW, Ma J. Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706. Schizophr Res. 2012; 141(1):40-7.

[25]   Zhu W, Meng L, Jiang C, Hou W, Xu J, Wang B, Lu S*. Induction of toll-like receptor 2 positive antigen-presenting cells in spleen of pristane-induced arthritis in rats. Mol Biol Rep. 2012; 39(4):3667-73.

[26]   Zhu W, Meng L, Jiang C, Xu J, Wang B, Han Y, Lu S*. Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats. Scand J Immunol. 2012; 76(3):263-70.

[27]   Zuo M, Zheng YW, Lu SM, Li Y, Zhang SQ. Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC-EGFR dual inhibitors. Bioorg Med Chem. 2012; 20(14):4405-12.

[28]   Cai Y, Cao YX, Lu SM, Xu CB, Cardell LO. Infliximab alleviates inflammation and ex vivo airway hyperreactivity in asthmatic E3 rats. Int Immunol. 2011; 23(7):443-51.

[29]   Hou WK, Meng LS, Zheng F, Wen YR, Zhu WH, Jiang CS, He XJ, Zhou Y, Lu SM*. Methotrexate ameliorates pristane-induced arthritis by decreasing IFN-γ and IL-17A expressions. J Zhejiang Univ Sci B. 2011; 12(1):40-6.

[30]   Li D, Wang X, Ren W, Ren J, Lan X, Wang F, Li H, Zhang F, Han Y, Song T, Holmdahl R, Lu S*. High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 rats. Mol Cell Endocrinol. 2011; 344(1-2):69-80.

[31]   Liu SZ, Tian LF, Xu P, Zhuang GH, Zheng F, Tian J, Ning QL, Zhu BF, Lu SM*, Yan H. Analysis of correlation between blood biochemical indicators and bone mineral density of post-menopausal women. Mol Biol Rep. 2011; 38(2):939-48.

[32]   Meng L, He X, Zhu W, Yang X, Jiang C, Sun Q, M B, Zhang S, Xue Q, Xie X, Lu S*. TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs. PLoS One. 2011; 6(2):e17252.（网络版，共11页）

[33]   Sun J, Sun Q, Lu S*. From selenoprotein to endochondral ossification: a novel mechanism with microRNAs potential in bone related diseases? Med Hypotheses. 2011; 77(5):807-11.

[34]   Sun J, Zhong N, Li Q, Min Z, Zhao W, Sun Q, Tian L, Yu H, Shi Q, Zhang F, Lu S*. MicroRNAs of rat articular cartilage at different developmental stages identified by Solexa sequencing. Osteoarthritis Cartilage. 2011; 19(10):1237-45.

[35]   Sun Q, Yang X, Asim MB, Jiao F, He X, Zhong B, Li D, Lu S*. Different challenge terms determine disease patterns of antigen-induced pulmonary inflammation in E3 rats. APMIS. 2011; 119(4-5):229-38.

[36]   Tian L, Wang W, Hou W, Tian J, Zhong N, Sun J, Guo D, Yao J, Xu P, Su P, He L, Lu S*. Autoimmune and inflammatory responses in Kashin-Beck disease compared with rheumatoid arthritis and osteoarthritis. Hum Immunol. 2011; 72(10):812-6.

[37]   Wang W, Zhong B, Sun J, Cao J, Tian J, Zhong N, Zhao W, Tian L, Xu P, Guo D, Ju X, Ma W, Li M, Hou W, Lu S*. Down-regulated HS6ST2 in osteoarthritis and Kashin-Beck disease inhibits cell viability and influences expression of the genes relevant to aggrecan metabolism of human chondrocytes. Rheumatology (Oxford). 2011; 50(12):2176-86.

[38]   Xie M, Dong Y, He L, Ren H, Ji Y, Lv S. Expression of VLA-4 molecule in PBMC from patients with hemorrhagic fever with renal syndrome. Inflamm Res. 2011; 60(7):613-7.

[39]   Xie M, Dong Y, Zhou Y, Ren H, Ji Y, Lv S. Levels of HTNV-specific CD8(+) T lymphocytes in PBMC from the patients with hemorrhagic fever with renal syndrome. Intern Emerg Med. 2011. [Epub ahead of print]

[40]   Zhang R, Valenzuela RK, Lu S, Meng L, Guo T, Du X, Kang W, Ma J. Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis. Schizophr Res. 2011; 133(1-3):159-64.

[41]   Zhang R, Lu SM*, Qiu C, Liu XG, Gao CG, Guo TW, Valenzuela RK, Deng HW, Ma J. Population-based and family-based association studies of ZNF804A locus and schizophrenia. Mol Psychiatry. 2011; 16(4):360-1.

[42]   Zhao S, Liu E, Wei K, Lu S, Chu Y, Li Y, Wang Y, Huang B, Chen Y, Yang P. Interferon plus Chinese herbs are associated with higher sustained virological response than interferon alone in chronic Hepatitis C: a meta-analysis of randomised trials. Antiviral Res. 2011; 89(2):156-64.

[43]   Zhong N, Zhang R, Qiu C, Yan H, Valenzuela RK, Zhang H, Kang W, Lu S, Guo T, Ma J. A novel replicated association between FXYD6 gene and schizophrenia. Biochem Biophys Res Commun. 2011; 405(1):118-21.

[44]   Zhu W, Meng L, Jiang C, He X, Hou W, Xu P, Du H, Holmdahl R, Lu S*. Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts. Arthritis Res Ther. 2011; 13(3):R103.

[45]   Guo Y, Yao F, Lu S, Cao DY, Reed WR, Zhao Y. The major histocompatibility complex genes are associated with basal pain sensitivity differences between Dark-Agouti and novel congenic DA.1U rats. Life Sci. 2010; 86(25-26):972-8.

[46]   Hou W, Meng L, Tian L, Zhu W, Jiang C, Lu S*. A systematic comparison between collagen-induced arthritis and pristane-induced arthritis in Dark Agouti rats. Clin Exp Rheumatol. 2010; 28(4):532-8.

[47]   Ma J, Li DM, Zhang R, Yang XD, Gao CG, Lu SM*, Wu SN, Wang L. Genetic analysis of glutamate cysteine ligase modifier (GCLM) gene and schizophrenia in Han Chinese. Schizophr Res. 2010; 119(1-3):273-4.

[48]   Meng L, Zhu W, Jiang C, He X, Hou W, Zheng F, Holmdahl R, Lu S*. Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. Arthritis Res Ther. 2010; 12(3):R103.

[49]   Raza Asim MB, Shahzad M, Yang X, Sun Q, Zhang F, Han Y, Lu S*. Suppressive effects of black seed oil on ovalbumin induced acute lung remodeling in E3 rats. Swiss Med Wkly. 2010; 140:w13128.

[50]   Yang W, Lv S*, Liu X, Liu H, Yang W, Hu F. Up-regulation of Tiam1 and Rac1 correlates with poor prognosis in hepatocellular carcinoma. Jpn J Clin Oncol. 2010; 40(11):1053-9.

[51]   Yang X, Sun Q, Asim MB, Jiang X, Zhong B, Shahzad M, Zhang F, Han Y, Lu S*. Nitric oxide in both bronchoalveolar lavage fluid and serum is associated with pathogenesis and severity of antigen-induced pulmonary inflammation in rats. J Asthma. 2010; 47(2):135-44.

[52]   Yu HB, Liu EQ, Lu SM, Zhao SH. Treatment with peginterferon versus interferon in Chinese patients with hepatitis B. Biomed Pharmacother. 2010; 64(8):559-64.

[53]   Zhao S, Liu E, Chen P, Cheng D, Lu S, Yu Q, Wang Y, Wei K, Yang P. A comparison of peginterferon α-2a and α-2b for treatment-naive patients with chronic hepatitis C virus: A meta-analysis of randomized trials. Clin Ther. 2010; 32(9):1565-77.

[54]   Jiang C, Meng L, Zhu W, Shahzad M, Yang X, Lu S*. Housekeeping gene stability in pristane-induced arthritis and antigen-induced pulmonary inflammation of rats. Inflamm Res. 2009; 58(9):601-9.

[55]   Li D, Ren W, Wang X, Wang F, Gao Y, Ning Q, Han Y, Song T, Lu S*. A modified method using TRIzol reagent and liquid nitrogen produces high-quality RNA from rat pancreas. Appl Biochem Biotechnol. 2009; 158(2):253-61.

[56]   Liu SZ, Yan H, Hou WK, Xu P, Tian J, Tian LF, Zhu BF, Ma J, Lu SM*. Relationships between endothelial nitric oxide synthase gene polymorphisms and osteoporosis in postmenopausal women. J Zhejiang Univ Sci B. 2009; 10(8):609-18.

[57]   Liu SZ, Yan H, Xu P, Li JP, Zhuang GH, Zhu BF, Lu SM*. Correlation analysis between bone mineral density and serum element contents of postmenopausal women in Xi'an urban area. Biol Trace Elem Res. 2009; 131(3):205-14.

[58]   Long JW, Yang XD, Cao L, Lu SM, Cao YX. Alteration of airway responsiveness mediated by receptors in ovalbumin-induced asthmatic E3 rats. Acta Pharmacol Sin. 2009; 30(7):965-72.

[59]   Ma J, Sun J, Zhang H, Zhang R, Kang WH, Gao CG, Liu HS, Ma XH, Min ZX, Zhao WX, Ning QL, Wang SH, Zhang YC, Guo TW, Lu SM*. Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample. Neurosci Lett. 2009; 462(2):105-8.

[60]   Shahzad M, Yang X, Raza Asim MB, Sun Q, Han Y, Zhang F, Cao Y, Lu S*. Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats. Pulm Pharmacol Ther. 2009; 22(1):37-43.

[61]   Yao F, Guo Y, Lu S, Sun C, Zhang Q, Wang H, Zhao Y. Mechanical hyperalgesia is attenuated by local administration of octreotide in pristane-induced arthritis in Dark-Agouti rats. Life Sci. 2008; 83(21-22):732-8.